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Synthesis 1989; 1989(6): 442-443
DOI: 10.1055/s-1989-27279
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An Efficient Synthesis of (±)-3-Amino-2-(4-chlorophenyl)-propylphosphonic Acid (PHACLOFEN)

Roger G. Hall*
  • *Central Research Laboratories, Ciba-Geigy PLC, Tenax Road, Trafford Park, Manchester M17 1WT, England
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Publication Date:
17 September 2002 (online)

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A three step, highly efficient synthesis of the GABA-B antagonist, Phaclofen, is described, which features a Michael addition of a phosphonate to a ß-nitrostyrene.