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Synthesis 1989; 1989(7): 539-541
DOI: 10.1055/s-1989-27310
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A Facile Chiral Synthesis of the Lactone Moiety of Compactin and Mevinolin from (R)-O-Benzylglycidol

Seiichi Takano* , Youichi Shimazaki, Yoshinori Sekiguchi, Kunio Ogasawara
  • *Pharmaceutical Institute, Tohoku University, Aobayama, Sendai 980, Japan
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Publication Date:
17 September 2002 (online)

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A facile chiral synthesis of (4R,6S)-4-hydroxy-6-hydroxymethyltetrahydro-2-pyrone (3) a key synthon for the lactone portion of compactin and mevinolin, is established using (R)-O-benzylglycidol as starting material.