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Synthesis 1989; 1989(9): 661-666
DOI: 10.1055/s-1989-27351
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Enzymatic Resolution of Medium-Ring Lactones. Synthesis of (S)-(+)-Phoracantholide I

Elie Fouque* , Gérard Rousseau
  • *Laboratoire des Carbocycles (Equipe associée au CNRS), I.C.M.O., Bât. 420, Université de Paris-Sud, F-91405 Orsay Cedex, France
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Publication Date:
17 September 2002 (online)

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The horse liver and pig liver esterase hydrolysis of racemic medium ring lactones gives with excellent enantiomeric excess the S- (or R) lactones and the corresponding R- (or S) hydroxy acids. This is the first general method to obtain optically pure medium ring lactones. Application to the preparation of (S)-(+)-Phoracantholide I is reported.