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Synthesis 1989; 1989(9): 715-718
DOI: 10.1055/s-1989-27372
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Facile Preparation of 6-Bromopyridine-2-carboxamide and Pyridine-2,6-dicarboxamide: Partial Aminocarbonylation of 2,6-Dibromopyridine

Hiroshi Horino* , Hiroyuki Sakaba, Mannosuke Arai
  • *Department of Chemistry, College of General Education, Tohoku University, Kawauchi, Sendai 980, Japan
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Publikationsdatum:
17. September 2002 (online)

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The palladium-catalyzed carbonylation of 2,6-dibromopyridine in the presence of primary amines under controlled conditions (carbon monoxide pressure) gives mainly N-aryl- or N-alkyl-6-bromopyridine-2-carboxamides accompanied by N,N′-diaryl- or N,N′-dialkylpyridine- 2,6-dicarboxamides. Further aminocarbonylation of the N-aryl- and N- alkyl-6-bromopyridine-2-carboxamides affords unsymmetric N,N′- diaryl, N-alkyl-N′-aryl-, or N,N′-dialkylpyridine-2,6-dicarboxamides.