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Synthesis 1989; 1989(11): 856-858
DOI: 10.1055/s-1989-27410
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Simple Three-Step Synthesis of (R)- and (S)-4-Amino-3-hydroxybutanoic Acid (GABOB) by Stereoselective Aldol Addition

Manfred Braun* , Delia Waldmüller
  • *Institut für Organische Chemie und Makromolekulare Chemie der Universität Düsseldorf, Universitätsstraße 1, D-4000 Düsseldorf 1, Federal Republic of Germany
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Publikationsdatum:
02. Mai 2002 (online)

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A simple synthesis of both (R)- and (S)-GABOB (5) is reported. In the key step, doubly deprotonated (R)- or (S)-2-Hydroxy-1,2,2-triphenylethyl acetate (HYTRA) (1) is added to Cbz-protected glycinal (2).