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Synthesis 1989; 1989(11): 869-870
DOI: 10.1055/s-1989-27417
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Convenient Syntheses of Nabumetone

Mohammad Aslam* , Varadaraj Elango, Kenneth G. Davenport
  • *Hoechst Celanese Corporation, Advanced Technology Group, Corpus Christi Technical Center, 1901 Clarkwood Road, Corpus Christi, Texas, 78409, USA
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Publikationsdatum:
02. Mai 2002 (online)

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Two novel and convergent one- and two-step syntheses of 4-(6′-methoxy-2′-naphthyl) -2-butanone (nabumetone, 6) via palladium-catalyzed coupling of 2-halo-6-methoxynaphthalene (1) with 3-buten-2-ol (2) and 3-buten-2-one (3) are described. The product is obtained in 60-92% yield.