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Synthesis 1989; 1989(11): 876-878
DOI: 10.1055/s-1989-27421
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Regioselective Alkylation of 4,6-Bis(methylthio)-1H-pyrazolo[3,4-d]pyrimidine

Neeraj Garg* , K. Avasthi, D. S. Bhakuni
  • *Medicinal Chemistry Division, Central Drug Research Institute, Lucknow 226001, India
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Publication Date:
02 May 2002 (online)

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Reaction of 4,6-bis(methylthio)-1H-pyrazolo[3,4-d]pyrimidine with alkyl halides in the presence of sodium hydride produces predominantly 2-alkyl-4,6-bis(methylthio)-2H-pyrazolo[3,4-d]pyrimidines in good yields.