Synthesis 1989; 1989(11): 880-882
DOI: 10.1055/s-1989-27423
communication
© Georg Thieme Verlag, Rüdigerstr. 14, 70469 Stuttgart, Germany. All rights reserved. This journal, including all individual contributions and illustrations published therein, is legally protected by copyright for the duration of the copyright period. Any use, exploitation or commercialization outside the narrow limits set by copyright legislation, without the publisher's consent, is illegal and liable to criminal prosecution. This applies in particular to photostat reproduction, copying, cyclostyling, mimeographing or duplication of any kind, translating, preparation of microfilms, and electronic data processing and storage.

Ozonolysis of Quinolines: A Versatile Synthesis of Polyfunctional Pyridines

C. O'Murchu*
  • *Forschungsabteilung Organischie Chemie, Lonza AG, CH-3930 Visp, Switzerland
Further Information

Publication History

Publication Date:
02 May 2002 (online)

A simple, safe and efficient procedure, easily adapted to a large scale, is described for the synthesis of substituted quinolines 2, which are readily oxidized by ozone in the presence of mineral acid, followed by an oxidative work up with hydrogen peroxide to afford substituted 2,3-pyridinedicarboxylic acids 3a-d, f and acyl pyridines 3e,g.