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Synthesis 1989; 1989(11): 880-882
DOI: 10.1055/s-1989-27423
DOI: 10.1055/s-1989-27423
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Ozonolysis of Quinolines: A Versatile Synthesis of Polyfunctional Pyridines
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Publication History
Publication Date:
02 May 2002 (online)
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A simple, safe and efficient procedure, easily adapted to a large scale, is described for the synthesis of substituted quinolines 2, which are readily oxidized by ozone in the presence of mineral acid, followed by an oxidative work up with hydrogen peroxide to afford substituted 2,3-pyridinedicarboxylic acids 3a-d, f and acyl pyridines 3e,g.