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Synthesis 1989; 1989(12): 898-901
DOI: 10.1055/s-1989-27425
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Stereocontrolled Total Synthesis of (5Z,8Z,10E,12R,14Z)-12-Hydroxy-5,8,10,14-icosatetraenoic Acid [(12R)-HETE]

K. C. Nicolaou* , J. Y. Ramphal, Y. Abe
  • *Department of Chemistry, University of Pennsylvania, Philadelphia, PA 19104, USA
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Publication Date:
02 May 2002 (online)

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A stereocontrolled convergent synthesis of (12R)-HETE (1) by palladium (0)/thallium hydroxide mediated coupling of vinylborane 2 with the vinyl iodide 3 is reported.