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Synthesis 1989; 1989(12): 949-950
DOI: 10.1055/s-1989-27441
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Efficient Conversion of Nitriles to Amides with Basic Hydrogen Peroxide in Dimethyl Sulfoxide

Alan R. Katritzky* , Boguslaw Pilarski, Laszlo Urogdi
  • *Department of Chemistry, University of Florida, Gainesville, FL 32691, USA
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Publication Date:
02 May 2002 (online)

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Nitriles 1 are efficiently transformed into N-unsubstituted amides 2 at 20°C in 5-30 mins in good yield and with high selectivity, using basic 30% hydrogen peroxide in dimethyl sulfoxide.