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Synlett 1990; 1990(9): 545-546
DOI: 10.1055/s-1990-21161
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Lipase-Catalyzed Resolution of (RS)-2-Methyl-4-phenylseleno-1-butanol: Synthesis of Enantiomerically Pure 2-Methyl-1,3-propanediol Derivatives

Patrizia Ferraboschi* , Paride Grisenti, Enzo Santaniello
  • *Istituto di Endocrinologia, Facoltà di Farmacia, Università degli Studi di Milano, I-20133 Milano, Italy
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Publikationsdatum:
08. März 2002 (online)

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Enantiomerically pure 2-methyl-1,3-propanediol derivatives 1b-d can be prepared in good yields from optically pure (R)-(+)-2-methyl-4-phenylseleno-1-butanol (2a) and (S)-(-)-acetate 2b, in turn prepared by an enantioselective transacetylation process in an organic solvent catalyzed by a lipase from Pseudomonas fluorescens (PFL).