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Synthesis 1990; 1990(3): 191-192
DOI: 10.1055/s-1990-26825
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Triazolines XVIII.1 Nickel Peroxide Oxidation of 4,5-Dihydro-1H-1,2,3-triazoles Bearing Sterically Crowded ortho-Substituted 5-Phenyl Groups

Pankaja K. Kadaba* , Steven B. Edelstein
  • *Division of Medicinal Chemistry and Pharmaceutics, College of Pharmacy A. B. Chandler Medical Center, University of Kentucky, Lexington, KY 40536-0082, USA
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Publication Date:
17 September 2002 (online)

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Nickel peroxide functions as an efficient oxidizing agent, superior to permanganate (phase-transfer catalytic system), in the oxidative dehydrogenation of 4,5-dihydro-1H-1,2,3-triazoles 1a-l, bearing sterically crowded ortho-substituted 5-phenyl groups, to 1H-1,2,3-triazoles 2a-l.