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Synthesis 1990; 1990(6): 459-460
DOI: 10.1055/s-1990-26903
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Synthesis of 2- and 3-Nitrooxypropanol by Chemoselective Reduction of Methyl 2-and 3-Nitrooxypropionoate

Toshihisa Ogawa* , Atsuro Nakazato, Masakazu Sato, Katsuo Hatayama
  • *Research Center, Taisho Pharmaceutical Co., Ltd., 1-403 Yoshino-cho, Omiya, Saitama 330, Japan
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Publication Date:
17 September 2002 (online)

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Highly chemoselective reduction of methyl 2- and 3-nitro-oxypropionate (9) and (12) with calcium borohydride was accomplished to give the desired 2- and 3-nitrooxypropanols (6 and 13) in good yields without affecting the nitrooxy group.