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Synthesis 1990; 1990(6): 485-487
DOI: 10.1055/s-1990-26913
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A Novel, Regioselective One-Pot Synthesis of 3-Aryl-2-chloroimidazo[1,2-a]pyridines and -pyrimidines

Benito Alcaide* , Gema Domínguez, Joaquín Plumet, Miguel A. Sierra, Angeles Monge, Virginia Pérez-Garcia
  • *Departamento de Química Orgánica, Facultad de Química, Universidad Complutense, E-28040 Madrid, Spain
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Publication Date:
17 September 2002 (online)

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Derivatives of 3-aryl-2-chloroimidazo[1,2-a]pyridines and -pyrimidines 2 are prepared in high yields from 2-[(2-aryl-1-hydroxy-2-oxoethyl)amino]pyridines and -pyrimidines 1 by reaction with thionyl chloride, followed by saturated sodium carbonate workup.