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Synthesis 1990; 1990(6): 493-495
DOI: 10.1055/s-1990-26916
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Convenient and Facile Syntheses of 6-Trifluoromethyl-3,6-dihydro-2H-1,3,4-oxadiazines

Yasuhiro Kamitori* , Masaru Hojo, Ryōichi Masuda, Seiji Ohara, Kazuyoshi Kawasaki, Yoshihiko Kawamura
  • *Department of Industrial Chemistry, Faculty of Engineering, Kobe University, Kobe 657, Japan
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Publication Date:
17 September 2002 (online)

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Several 6-trifluoromethyl-3,6-dihydro-2H-1,3,4-oxadiazines 2 were synthesized in good yields by treatment of trifluoroacetylated hydrazones 1, prepared from substituted benzaldehyde and alkanal dialkylhydrazones and trifluoroacetic anhydride, with trifluoroacetic acid at 25°C or acetic acid at 50°C. This is an improved method for the synthesis of 2 compared to previous methods developed in this laboratory.