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Synthesis 1990; 1990(7): 628-630
DOI: 10.1055/s-1990-26963
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Convenient Syntheses of 1,3-Dihydro-1-oxo-4-isobenzofurancarboxylic Acid, 1,3-Dihydro-3-oxo-4-isobenzofurancarboxylic Acid, and the Homologous Acetic Acids

Richard W. Skeean* , O. P. Goel
  • *Parke-Davis Pharmaceutical Research Division, Warner-Lambert, Company, Ann Arbor, MI 48105, USA
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Publication Date:
17 September 2002 (online)

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1-Dihydro-1-oxo- and 1,3-dihydro-3-oxo-4-isobenzofurancarboxylic acids were prepared in good yield by extensions of the Davies and Perkin synthesis of phthalide and were homologated to the corresponding acetic acid derivatives via the Arndt-Eistert reaction.