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Synthesis 1990; 1990(8): 659-660
DOI: 10.1055/s-1990-26972
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Studies on Pyrazines; Part 20.1 A Simple Synthesis of 5-Substituted 2-Amino-3-cyanopyrazines: Useful Intermediates for Pteridine Synthesis

Nobuhiro Sato* , Ryo Takeuchi
  • *Department of Chemistry, Yokohama City University, Yokohama 236, Japan
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Publication Date:
17 September 2002 (online)

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A new and convenient synthesis of 5-substituted 2-amino-3-cyanopyrazines 3 involving cyanation of the corresponding 2-amino-3-bromopyrazines 2 with sodium dicyanocuprate is reported.