Synthesis 1990; 1990(8): 679-680
DOI: 10.1055/s-1990-26979
paper
© Georg Thieme Verlag, Rüdigerstr. 14, 70469 Stuttgart, Germany. All rights reserved. This journal, including all individual contributions and illustrations published therein, is legally protected by copyright for the duration of the copyright period. Any use, exploitation or commercialization outside the narrow limits set by copyright legislation, without the publisher's consent, is illegal and liable to criminal prosecution. This applies in particular to photostat reproduction, copying, cyclostyling, mimeographing or duplication of any kind, translating, preparation of microfilms, and electronic data processing and storage.

Unequivocal Preparation of 4- and 5-Acyl-2-aminophenols

Hocine Aichaoui* , Isabelle Lesieur, Jean-Pierre Hénichart
  • *Institut de Chimie Pharmaceutique, Faculté de Pharmacie, Rue Prof. Laguesse, 59045 Lille, France
Further Information

Publication History

Publication Date:
17 September 2002 (online)

Unequivocal methods for the specific preparation of 4- or 5-acyl-2-aminophenols are reported. 5-Acyl-2-aminophenols are obtained by ring opening with dilute sodium hydroxide of 2(3H)-benzoxa-zolinones acylated at position 6. 4-Acyl-2-aminophenols are obtained by acylation of 2-acetamidophenol in the presence of aluminum chloride/dimethylformamide followed by a deprotection of the amino group.