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Synthesis 1990; 1990(8): 679-680
DOI: 10.1055/s-1990-26979
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Unequivocal Preparation of 4- and 5-Acyl-2-aminophenols

Hocine Aichaoui* , Isabelle Lesieur, Jean-Pierre Hénichart
  • *Institut de Chimie Pharmaceutique, Faculté de Pharmacie, Rue Prof. Laguesse, 59045 Lille, France
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Publication History

Publication Date:
17 September 2002 (online)

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Unequivocal methods for the specific preparation of 4- or 5-acyl-2-aminophenols are reported. 5-Acyl-2-aminophenols are obtained by ring opening with dilute sodium hydroxide of 2(3H)-benzoxa-zolinones acylated at position 6. 4-Acyl-2-aminophenols are obtained by acylation of 2-acetamidophenol in the presence of aluminum chloride/dimethylformamide followed by a deprotection of the amino group.