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Synthesis 1990; 1990(8): 701-702
DOI: 10.1055/s-1990-26987
DOI: 10.1055/s-1990-26987
paper
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Low-Valent Titanium Induced Reductive Cyclization of Nitriles to Symmetrically Substituted Tetraalkylpyrazines
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Publication History
Publication Date:
17 September 2002 (online)
Reductive cyclization of nitriles 1 induced by titanium tetrachloride/zinc provides an efficient general synthesis of symmetrically substituted tetraalkylpyrazines 2.