Trimethylamine-Borane a Useful Reagent in the One-Pot Preparation of Carboxylic Esters from Carboxylic Acids

Giuseppe Trapani; Antonia Reho; Andrea Latrofa; Gaetano Liso

doi:10.1055/s-1990-27034

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Synthesis 1990; 1990(9): 853-854
DOI: 10.1055/s-1990-27034

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Trimethylamine-Borane a Useful Reagent in the One-Pot Preparation of Carboxylic Esters from Carboxylic Acids

Giuseppe Trapani^* , Antonia Reho, Andrea Latrofa, Gaetano Liso

^*Dipartimento Farmaco-chimico, Università degli Studi di Bari, Via G. Amendola 173, I-70126 Bari, Italy

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Publication Date:
17 September 2002 (online)

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The carboxylic esters 2a-h (R¹CO₂CH₂R¹) and 4a-d (R¹CO₂CH₂R²) are synthesized from alkyl or aryl carboxylic acids, a one-pot reaction involving in situ reduction followed by esterification, both steps are mediated by trimethylamine-borane.