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Synthesis 1990; 1990(10): 881-882
DOI: 10.1055/s-1990-27040
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Sterically Hindered Bases. Synthesis of 2,4,6-Trisubstituted Pyrimidines

A. García Martínez* , A. Herrera Fernandez, Roberto Martínez Alvarez, M. C. Silva Losada, D. Molero Vilchez, L. R. Subramanian, M. Hanack
  • *Departamento de Química Organíca, Facultad de Ciencias Químicas, Universidad Complutense, E-28040 Madrid, Spain
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Publication Date:
17 September 2002 (online)

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A new method for the synthesis of sterically hindered pyrimidines 7 by the reaction of alkynes 5 with nitriles 6 in the presence of trifluoromethanesulfonic acid is described. The pKa*-values of some of the synthesized pyrimidines 7, which can be used as nonnucleophilic bases, were determined in 50% aqueous ethanol.