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Synthesis 1990; 1990(10): 893-895
DOI: 10.1055/s-1990-27045
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Synthesis of 5-Amino-4-aminocarbonyl-1-hydroxyimidazole and its Conversion to Novel Acyclic Analogues of AICA Riboside

Michael R. Harnden* , L. John Jennings, Colin M. D. Mckie, Ann Parkin
  • *Beecham Pharmaceuticals, Yew Tree Bottom Road, Epsom, Surrey KT18 5XQ, England
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Publication Date:
17 September 2002 (online)

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A new, improved procedure for the preparation of 5-amino-4- aminocarbonyl-1-hydroxyimidazole from N′-benzyloxy-N,N- dimethylformamidine and 2-amino-2-cyanoacetamide is described. O-Alkylation of this 1-hydroxyimidazole with appropriately functionalised alkyl halides or sulphonates provides an efficient route to acyclic imidazole nucleoside analogues.