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Synthesis 1990; 1990(10): 909-911
DOI: 10.1055/s-1990-27050
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Application of Wittig Reaction to Adenosine Derivatives

Zhang Jun-Dong* , Zhang Li-He
  • *School of Pharmaceutical Sciences, Beijing Medical University, Beijing 100083, People's Republic of China
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Publication Date:
17 September 2002 (online)

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2′,3′-O-Ethoxymethyleneadenosine 5′-aldehyde (3)was reacted with Wittig reagents 4 and 5 to give the corresponding α,β- unsaturated adenosine esters 6 and 7. The dehydrated compounds 9 and 10 were separated from this reaction and inversion of configuration at C-3′ in ribofuranoside was observed.