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Synlett 1990; 1990(2): 117-118
DOI: 10.1055/s-1990-34715
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ß-Trimethylsilylethoxymethyl Chloride as a Formaldehyde Equivalent in Aldol-Type Reactions

David Crich* , Linda B. L. Lim
  • *Department of Chemistry, University College of London, 20 Gordon Street, London WC1II 0AJ, England
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Publication Date:
08 March 2002 (online)

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ß-Trimethylsilylethoxymethyl chloride reacts with a variety of lithium enolates and lithium salts of stabilised carbanions to give the aldol products conveniently protected as their ß-trimethylsilylethyl ethers.