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Synlett 1991; 1991(1): 11-19
DOI: 10.1055/s-1991-20611
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Plant Cell Cultures and Synthetic Chemistry - A Potentially Powerful Route to Complex Natural Products

James P. Kutney*
  • *Department of Chemistry, University of British Columbia, 2036 Main Mall, Vancouver, B.C., Canada V6T 1Y6
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Publication Date:
07 March 2002 (online)

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A general overview of the combined use of plant cell cultures and synthetic chemistry to afford efficient routes to complex natural products and related analogues is presented. Several specific examples illustrate the overall strategy and rationale involved. 1. Introduction 2. Studies with Cell Cultures of C. roseus-The Vinblastine Family 2.1. Biotransformation and Biosynthetic Studies: Enzymatic Reactions versus Laboratory Syntheses 2.2. Enzyme Immobilization 2.3. Biomimetic Studies - Biosynthetic Information Sets the Stage for an Efficient Synthesis of Vinblastine 2.4. Synthetic Studies - A Highly Efficient and Commercially Important Route to Vinblastine 3. Studies with Cell Cultures of C. roseus - The Podophyllotoxin Family 4. Conclusion