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Synlett 1991; 1991(4): 279-282
DOI: 10.1055/s-1991-20708
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An Enantiocontrolled Synthesis of Phytol by Reiterative Application of the Chiral 3-Hydroxyalkyne Formation Reaction

Seiichi Takano* , Takumichi Sugihara, Kunio Ogasawara
  • *Pharmaceutical Institute, Tohoku University, Aobayama, Sendai 980, Japan
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Publication Date:
07 March 2002 (online)

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An enantiocontrolled synthesis of phytol (1) has been established by reiterative application of the chiral 3-hydroxyalkyne formation reaction starting from (E)-4-benzyloxy-2-butene-1-ol (7) via (R)-citronellal (19) and (R,R)-hexahydrofarnesol [32; (3R, 7R)-3,7,11-trimethyl-1-dodecanol].