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Synthesis 1991; 1991(1): 46-48
DOI: 10.1055/s-1991-26377
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A Facile and Convenient Synthesis of 5,5-Dialkylthio- and 5-Alkyl(or Aryl)thio-2,4-pentadienoic Acids

Masaru Hojo* , Ryoichi Masuda, Etsuji Okada
  • *Department of Industrial Chemistry, Faculty of Engineering, Kobe University, Kobe 657, Japan
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Publication Date:
17 September 2002 (online)

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The hydrolysis of 6,6-dialkylthio- and 6-alkyl(or aryl)thio-1,1,1-trifluoro-3,5-hexadien-2-ones 2, 5 with potassium hydroxide in ethanol proceeds quite easily to give the corresponding 2,4-pentadienoic acids 3, 6, respectively, in excellent yields. Bistrifluoroacetyl compounds 8,10a, b give corresponding monocarboxylic acids 6a, 3a, b in high yields, with accompanied monodecarboxylation.