Download PDF
Synthesis 1991; 1991(3): 195-198
DOI: 10.1055/s-1991-26416
paper
© Georg Thieme Verlag, Rüdigerstr. 14, 70469 Stuttgart, Germany. All rights reserved. This journal, including all individual contributions and illustrations published therein, is legally protected by copyright for the duration of the copyright period. Any use, exploitation or commercialization outside the narrow limits set by copyright legislation, without the publisher's consent, is illegal and liable to criminal prosecution. This applies in particular to photostat reproduction, copying, cyclostyling, mimeographing or duplication of any kind, translating, preparation of microfilms, and electronic data processing and storage.

An Improved Synthesis of 2-Diazo-1,3-diketones

V. V. Popic* , S. M. Korneev, V. A. Nikolaev, I. K. Korobitsyna
  • *Department of Chemistry, Leningrad State University, Leningrad, SU-198904, USSR
Further Information

Publication History

Publication Date:
17 September 2002 (online)

 PDF Download  Permissions and Reprints All articles of this category

The sodium hydride/dibenzo-18-crown-6 ether system was found to be an effective base for the synthesis of 1,3-diketones by the Claisen condensation. The use of potassium fluoride (with or without crown ether) as the base in diazo-transfer reactions extends this reaction to the synthesis of hindered diazo diketones. In the case of isomeric 1,3-diketones, the stereoselectivity of the process considerably rises.