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Synthesis 1991; 1991(5): 350-352
DOI: 10.1055/s-1991-26462
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Synthesis of Hydrazides Through an Enzymatic Hydrazinolysis Reaction

Covadonga Astorga* , Francisca Rebolledo, Vicente Gotor
  • *Departamento de Química Organometálica, Facultad de Química, Universidad de Oviedo, E-33071 Oviedo, Spain
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Publication Date:
29 April 2002 (online)

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Amano PS lipase catalyzes the reaction of formic hydrazide, acetic hydrazide and methyl carbazate with various esters: α, β-unsaturated hydrazides were obtained by using methyl acrylate or vinyl crotonate. The reaction with ethyl (±)-2-chloropropionate yields the corresponding hydrazide in good yield but with moderate enantiomeric excess.