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Synthesis 1991; 1991(6): 441-442
DOI: 10.1055/s-1991-26487
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An Improved Acid Chloride Preparation via Phase Transfer Catalysis

Kenneth A. Burdett*
  • *The Dow Chemical Company, The Central Research Laboratory, Midland, MI-48674, USA
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Publication Date:
29 April 2002 (online)

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Phase transfer catalysis has been found to be effective for the rapid conversion of carboxylic acids in high yield to the corresponding acid chlorides. The procedure is well suited for acids that exhibit low solubilities in normal organic solvents.