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Synthesis 1991; 1991(6): 474-476
DOI: 10.1055/s-1991-26497
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A Facile Synthesis of 3-Substituted Glutaraldehyde Monoacetals from Nitriles

Giorgio Chelucci*
  • *Dipartimento di Chimica, Universita' di Sassari, via Vienna 2, I-07100 Sassari, Italy
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Publication History

Publication Date:
29 April 2002 (online)

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3-Substituted glutaraldehyde monoacetals 7 have been prepared in 48-58% overall yield, consecutively by the alkylation of nitriles, first with 2-bromo-1,1-diethoxyethane (2) and then with 2-iodomethyl-1,3-dioxolane (4), followed by removal of the cyano group and selective hydrolysis of the diethyl acetal function.