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Synthesis 1991; 1991(6): 497-498
DOI: 10.1055/s-1991-26505
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Synthese von 4-Thiazolidinessigsäuren und ß-Homopenicillamin

Jürgen Martens* , Jürgen Kintscher, Wolfgang Arnold
  • *Fachbereich Chemie (Organische Chemie) der Universität Oldenburg, Ammerländer Heerstraße 114-118, D-2900 Oldenburg, Germany
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Publication Date:
29 April 2002 (online)

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Synthesis of 4-Thiazolidineacetic Acids and ß-Homopenicillamine 4-Thiazolidineacetic acids 2, previously unknown homologs of the intensively examined thiazolidine-4-carboxylic acids, were readily prepared by addition of malonic acid to the azomethine group of various 2,5-dihydro-1,3-thiazoles 1, followed by decarboxylation at room temperature. Hydrolysis of 2,2,5,5-tetramethyl-4-thiazolidineacetic acid (2e) lead to ß-homopenicillamine 3, a new homolog of the pharmacologically interesting penicillamine, and its thiolactone hydrochloride 4.