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Synthesis 1991; 1991(7): 526-528
DOI: 10.1055/s-1991-26507
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Improved Synthesis of L-Homoserine Derivatives from L-Aspartic Acid

Horst C. Uzar*
  • *Institut für Organische Chemie, Universität-GH-Siegen, Adolf-Reichwein-Str., D-5900 Siegen, Germany
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Publication History

Publication Date:
29 April 2002 (online)

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N-Alkoxycarbonyl-L-homoserine lactones (α-alkoxycarbonyl- amino-γ-butyrolactones) were prepared by selective esterification of L-aspartic acid followed by N-protection, precipitation of the dicyclohexylammonium salts, chemoselective reduction with lithium borohydride, and cyclization to the corresponding γ-lactones during isolation.