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Synthesis 1991; 1991(8): 621-624
DOI: 10.1055/s-1991-26528
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Formation of Azomethines from 2-Aminothiazoles and (Heterocyclic) Aromatic Aldehydes

Christopher Hopkinson* , George Denis Meakins, Roberts James Purcell
  • *Dyson Perrins Laboratory, Oxford University, Oxford, OXI 3QY, England
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Publication Date:
29 April 2002 (online)

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Reexamination of previous work and new studies show that the reactions of 2-aminothiazoles with (heterocyclic) aromatic aldehydes are not straightforward; there are wide divergencies in behaviour between the various amine-aldehyde pairs. Simple efficient procedures for preparing 2-(alkylideneamino)thiazole derivatives and [bis(thiazol-2-ylamino)methyl]arenes have been developed.