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Synthesis 1991; 1991(9): 722-726
DOI: 10.1055/s-1991-26556
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Efficient Synthesis of (E)-9-Chloro-4-methyl-8-oxo-4-nonenoic Acid from 4-Chloro-2-methyl-2-butene

Hisao Takayanagi* , Tadashi Shirasaka, Yoshiharu Morita
  • *Pharmaceuticals Laboratory, Research Center, Mitsubishi Kasei Corporation, 1000, Kamoshida-cho, Midori-ku, Yokohama, Kanagawa 227, Japan
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Publication Date:
29 April 2002 (online)

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(E)-9-Chloro-4-methyl-8-oxo-4-nonenoic acid, a useful intermediate in the synthesis of the potent antigestational agent ORF-13811 (a 3,8-dioxabicyclo[3.2.1]octane derivative), is efficiently prepared from 4-Choro-2-methyl-2-butene by using the ortho ester Claisen rearrangement.