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Synthesis 1991; 1991(10): 832-834
DOI: 10.1055/s-1991-26584
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Eine neue Synthese von (S)-β-Methyl-γ-butyrolacton und (S)-4-Benzyloxy-3-methylbutansäure

Ulrich Berens* , Hans-Dieter Scharf
  • *Institut für Organische Chemie der RWTH Aachen, Prof. -Pirlet-Str. 1, D-5100 Aachen, Germany
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Publication Date:
29 April 2002 (online)

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A New Synthesis of (S)-β-Methyl-γ-butyrolactone and (S)-4-Benzyloxy-3-methylbutanoic Acid A stereoselective synthesis of (S)-β-methyl-γ-butyrolactone [(S)-4,5-dihydro-4-methyl-2(3H)-furanone, 1] and of (S)-4-benzyloxy-3-methylbutanoic acid (2) is described. Both compounds are prepared starting from inexpensive L-ethyl lactate with overall yields of 26% and 30%, respectively. The products are valuable chiral building blocks.