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Synthesis 1991; 1991(10): 891-894
DOI: 10.1055/s-1991-26603
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An Enzymatic Route to Florfenicol

Jon E. Clark* , Peter A. Fischer, Doris P. Schumacher
  • *Chemical Process Research and Development, Schering-Plough Research, Bloomfield, NJ 07003, USA
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Publikationsdatum:
29. April 2002 (online)

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Racemic ethyl threo-3-(4-methylthiophenyl)serinate is resolved by enzymatic hydrolysis using protease from Streptomyces griseus and both stereoisomers are converted to D-threo-4, 5-dihydro-5-(4-methylsulfonylphenyl)-2-phenyl-4-oxazolemethanol, thereby giving a formal synthesis of florfenicol.