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Synthesis 1991; 1991(11): 999-1000
DOI: 10.1055/s-1991-26628
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Studies on Isocyanides and Related Compounds. Synthesis of Benzofuran Derivatives

Ricardo Bossio* , Stefano Marcaccini, Paola Paoli, Roberto Pepino, Cecilia Polo
  • *CNR, Centro di Studio sulla Chimica e la Struttura dei Composti Eterociclici e loro Applicazioni, Dipartimento di Chimica Organica "Ugo Schiff", Universita' di Firenze, via G. Capponi 9, I-50121 Firenze, Italy
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Publication Date:
29 April 2002 (online)

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The reaction between 2-hydroxybenzaldehyde (1a), isocyanides 2, and ammonium formate, in the conditions of the Ugi four-component condensation, affords 2-alkylamino- and 2-arylamino-3-[(2-hydroxybenzylidene)amino]benzofurans 3a-c. Analogously by employing 5-bromo-2-hydroxybenzaldehyde (1b) as the carbonyl compound, 2-alkylamino- and 2-arylamino-5-bromo-3- [(5-bromo-2-hydroxybenzylidene)amino]benzofurans 3d-f are obtained.