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Synthesis 1991; 1991(11): 1023-1026
DOI: 10.1055/s-1991-26638
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Resolution of 4-Phenyl-2-pyrrolidinone: A Versatile Synthetic Intermediate

Robert E. Zelle*
  • *Division of Cardiovascular Research, D-47C, AP10 Pharmaceutical Products Division, Abbott Laboratories, Abbott Park, IL 60064, USA
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Publikationsdatum:
29. April 2002 (online)

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A resolution of 4-phenyl-2-pyrrolidinone is described. The resulting enantiomerically pure pyrrolidinones are exploited as precursor to 3-phenylpyrrolidines and 3-phenyl-γ-amino acids (4-amino-3-phenylbutanoic acid derivatives).