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Synlett 1992; 1992(1): 48-50
DOI: 10.1055/s-1992-21261
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Optically Active Arylpropionic Acids from the Stereoselective Alkylation of Chiral Imide Enolates1

Antoine Fadel*
  • *Laboratoire des Carbocycles, associé au CNRS, Institut de Chimie Moléculaire d'Orsay, Bât. 420, Université de Paris-Sud, F-91405 Orsay, France
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Publication Date:
18 September 2002 (online)

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The chiral imides 4 - 6 (3-arylacetyl-4-isopropyl/benzyl-2-oxazolidinones) were alkylated via their imide enolates with methyl iodide, then subsequent removal of the chiral auxiliary provided readily with high stereoselectivity the (S)-2 -arylpropionic acids 1 - 3 in good overall yield.