Download PDF
Synlett 1992; 1992(1): 79-80
DOI: 10.1055/s-1992-21273
letter
© Georg Thieme Verlag, Rüdigerstr. 14, 70469 Stuttgart, Germany. All rights reserved. This journal, including all individual contributions and illustrations published therein, is legally protected by copyright for the duration of the copyright period. Any use, exploitation or commercialization outside the narrow limits set by copyright legislation, without the publisher's consent, is illegal and liable to criminal prosecution. This applies in particular to photostat reproduction, copying, cyclostyling, mimeographing or duplication of any kind, translating, preparation of microfilms, and electronic data processing and storage.

Synthesis of 7-Formylindole Using the Bartoli Indole Methodology

David R. Dobson* , Jeremy Gilmore, David A. Long
  • *Chemistry Department, Eli Lilly and Co. Ltd., Lilly Research Centre Ltd., Erl Wood Manor, Windlesham, Surrey GU20 6PH, England
Further Information

Publication History

Publication Date:
18 September 2002 (online)

  PDF Download  Permissions and Reprints All articles of this category

The Bartoli methodology provides a convenient route for the synthesis of 7-formylindole, either indirectly via an improved metalation of 7-bromoindole using sodium hydride/butyllithium or two equivalents of butyllithium or directly by use of an acetal protected 2-nitrobenzaldehyde and vinylmagnesium bromide.