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Synlett 1992; 1992(2): 117-118
DOI: 10.1055/s-1992-21283
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Synthesis of (+)-Leukotriene B4 (LTB4) Methyl Ester and (-)-(5R)-LTB4 Methyl Ester via Pyrylium Methodology

Bennett C. Borer* , Richard J. K. Taylor
  • *School of Chemical Sciences, University of East Anglia, Norwich NR4 7TJ, England
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Publication Date:
08 March 2002 (online)

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The title compounds (5S)- and (5R)-leukotriene B4 methyl esters (1) and (2), have been prepared from 3-nonenal by a short convergent synthetic route which utilises addition of 3-(tert-butyldimethylsiloxy)-1,5-undecadienyllithium (8) to pyrylium tetrafluoroborate for the construction of the crucial Z,E,E-triene unit.