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Synlett 1992; 1992(4): 297-298
DOI: 10.1055/s-1992-21345
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Synthesis of 1,4-Dihydropyridines under Microwave Irradiation

Ramón Alajarín* , Juan J. Vaquero, José L. García Navío, Julio Alvarez-Builla
  • *Departamento de Química Orgánica, Universidad de Alcalá, E-28871 Alcalá de Henares, Madrid, Spain
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Publication History

Publication Date:
08 March 2002 (online)

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A domestic microwave oven has been used to accelerate the Hantzsch synthesis of dialkyl 4-aryl-2,6-dimethyl-1,4-dihydro-3,5-pyridinedicarboxylates 1 and a variant leading to 4,4-dialkyl-2,6-dimethyl-1,4-dihydro-3,5-pyridinedicarbonitriles 2. In comparison with the traditional reflux method, similar or higher yields were obtained.