Download PDF
Synlett 1992; 1992(9): 709-710
DOI: 10.1055/s-1992-21462
letter
© Georg Thieme Verlag, Rüdigerstr. 14, 70469 Stuttgart, Germany. All rights reserved. This journal, including all individual contributions and illustrations published therein, is legally protected by copyright for the duration of the copyright period. Any use, exploitation or commercialization outside the narrow limits set by copyright legislation, without the publisher's consent, is illegal and liable to criminal prosecution. This applies in particular to photostat reproduction, copying, cyclostyling, mimeographing or duplication of any kind, translating, preparation of microfilms, and electronic data processing and storage.

A Short Synthesis of the Glycine Antagonist (3R,4R)-3-Amino-1-hydroxy-4-methyl-pyrrolidin-2-one (L-687,414)

M. Jonathan Fray* , David J. Bull, Keith James
  • *Pfizer Central Research, Sandwich, Kent CT13 9NJ, England
Further Information

Publication History

Publication Date:
08 March 2002 (online)

  PDF Download  Permissions and Reprints All articles of this category

A new, short synthesis of the glycine antagonist 3R,4R)-3-amino-1-hydroxy-4-methylpyrrolidin-2-one (L-687,414) (1) is described, which proceeds in six steps (14% overall yield), starting from commercially available (S)-β-methyl-γ-butyrolactone (4).