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Synlett 1992; 1992(9): 715-717
DOI: 10.1055/s-1992-21465
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Palladium-Catalyzed Cross-Coupling Reactions in a Homogeneous Aqueous Medium

Jean Pierre Genet* , Errol Blart, Monique Savignac
  • *Laboratoire de Synthèse Organique, Associé au CNRS, Ecole Nationale Supérieure de Chimie de Paris, 11 rue Pierre et Marie Curie, F-75231 Paris, France
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Publication Date:
08 March 2002 (online)

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A palladium(0) water-soluble catalyst prepared in situ from palladium(II) acetate-trisodium 3,3′,3″-phosphinetriyl-tribenzenesulfonate is an efficient catalyst for various cross-coupling reactions. Examples of the coupling in this aqueous media include: inter- and intramolecular Heck reactions (acyclic and cyclic alkenes); terminal alkynes [without any copper(I) promoter]; phenyl boronic acid with iodoaromatic compounds or vinyl halides; and allylic substitution with carbonucleophiles and nitrogen nucleophiles such as primary amines.