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Synlett 1992; 1992(9): 747-748
DOI: 10.1055/s-1992-21479
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Aluminum Chloride Promoted Aminolysis of Lactams

Eric Bon* , Dennis C. H. Bigg, Guy Bertrand
  • *Laboratoire de Chimie de Coordination du CNRS, 205 route de Narbonne, F-31077 Toulouse Cedex, France
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Publication Date:
08 March 2002 (online)

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Aluminum chloride effectively promotes nucleophilic ring-opening reactions of N-benzoyl-, N-pivaloyl-, or N-tert-butoxycarbonyllactams (2) with a variety of primary and secondary amines. The influence of the size of the lactam ring, the environment of the carbonyl groups, and the nature of the amine on the regioselectivity of the reaction have been studied.