Studies on the Chemistry of Mitomycins

Masaji Kasai; Motomichi Kono

doi:10.1055/s-1992-21490

Synlett 1992; 1992(10): 778-790
DOI: 10.1055/s-1992-21490

account

© Georg Thieme Verlag, Rüdigerstr. 14, 70469 Stuttgart, Germany. All rights reserved. This journal, including all individual contributions and illustrations published therein, is legally protected by copyright for the duration of the copyright period. Any use, exploitation or commercialization outside the narrow limits set by copyright legislation, without the publisher's consent, is illegal and liable to criminal prosecution. This applies in particular to photostat reproduction, copying, cyclostyling, mimeographing or duplication of any kind, translating, preparation of microfilms, and electronic data processing and storage.

Studies on the Chemistry of Mitomycins

Masaji Kasai^* , Motomichi Kono

^*Pharmaceutical Research Laboratories, Kyowa Hakko Kogyo Co., Ltd., 1188 Shimotogari, Nagaizumi, Sunto, Shizuoka 411, Japan

Abstract

PDF Download All articles of this category

An overview of the systematic study on the mitomycin family is presented. New naturally occurring mitomycins and related novel compounds were isolated from a fermentation broth. Their structures were elucidated primarily based on NMR and MS spectra. Synthetic methods to afford related analogs have been developed. The extension of such study made it possible to give novel mitomycin analogs. 1. Introduction 2. Identification and Structural Elucidation of Mitomycins D, E, F, G, I, J, K, L, and M 3. Derivation of New Mitomycins Structurally Similar to Naturally Occurring Mitomycins from Conventional Mitomycins 3.1. 1a-Demethylmitomycins G and K 3.2. 9-epi-Mitomycins B and D 4. Identification and Structural Elucidation of Albomitomycin A and Isomitomycin A 5. "Mitomycin Rearrangement" and Effective Derivation of Albomitomycin A and Isomitomycin A from Mitomycin A 6. Derivation of New Mitomycins Based on the Novel Chemistry of Isomitomycin A 7. Derivation of New Mitomycins Based on the Analysis of 10-Decarbamoylation Reaction 8. Modifications of the C-6 Methyl and C-6 Positions 8.1. Specific Labeling of the C-6 Methyl Group 8.2. Derivation of Mitomycin C Labeled at C-6 by ¹³CH₃, and C²H₃ 9. Conclusion and Outlook

PDF (1020 kb)