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Synlett 1992; 1992(4): 351-353
DOI: 10.1055/s-1992-22012
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A Convenient Access to 2-exo-Methylenecephem1

Hideo Tanaka* , Yutaka Kameyama, Shin-ichi Sumida, Takashi Shiroi, Michio Sasaoka, Masatoshi Taniguchi, Sigeru Torii
  • *Department of Applied Chemistry, Faculty of Engineering, Okayama University, Okayama 700, Japan
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Publication Date:
08 March 2002 (online)

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One-pot transformation of 3-methyl-2-(2-oxo-4-phenylsulfonylthio-1-azetidinyl)-2,4-pentadienoates 8, derived from penicillins, into 2-exo-methylenecephems 1 has been achieved by successive treatment with sodium benzenesulfinate and 1,8-diazabicyclo[5.4.0] undec-7-ene (DBU) in dimethylformamide.