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Synthesis 1992; 1992(4): 353-354
DOI: 10.1055/s-1992-26105
short paper
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α-Benzyl-γ-L-glutamyltaurine as a Useful Intermediate for the Synthesis of a Brain-Peptide, γ-L-Glutamyltaurine1

Kunihiko Higashiura* , Kazuharu Ienaga
  • *Department of Natural Products Chemistry, Institute of Bio-Active Science (IBAS), Nippon Zoki Pharmaceutical Co. Ltd., Yashiro-cho, Kato-gun, Hyogo 673-14, Japan
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Publication Date:
17 September 2002 (online)

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The synthesis of a neuropeptide, γ-L-glutamyltaurine (3a), was achieved via α-benzyl-γ-L-glutamyltaurine (2a) as a useful intermediate, which was prepared from α-benzyl N-tert-butoxycarbonyl-L-glutamate (1a) and taurine (2-aminoethanesulfonic acid) by active ester method. The preparation of its α-isomer 3b was also described.