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Synthesis 1992; 1992(4): 391-394
DOI: 10.1055/s-1992-26120
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Methyl (E)-4-Chloro-3-methoxy-2-butenoate: An Extremely Versatile Four Carbon Building Block

Laurent Duc* , John F. Mcgarrity, Thomas Meul, Aleksander Warm
  • *LONZA AG, CH-3930 Visp, Switzerland
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Publication History

Publication Date:
17 September 2002 (online)

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Methyl (E)-4-chloro-3-methoxy-2-butenoate (3a) is inexpensively prepared from methyl 4-chloroacetoacetate using thionyl chloride and methanol on an industrial scale. Many nucleophilic substitution reactions of chloride, which are impossible with the unprotected parent compound proceed readily with 3a.